Biomedical innovation and translation are increasingly emphasizing research using “big data.” The hope is that big data methods will both speed up research and make its results more applicable to “real-world” patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, (...) and data analysis techniques. While such advances will likely go some way towards resolving technical and methodological issues, we believe that the epistemological issues raised by big data research have important ethical implications and raise questions about the very possibility of big data research achieving its goals. (shrink)

The purpose of this paper is to determine whether there is a relationship between a person's degree of religiousness and corporate social responsibility orientation. A total of 411 managers and 506 students from seven universities were surveyed. The statistical analysis showed that religiousness does influence students' orientation toward the economic, ethical, and philanthropic responsibilities of business. It does not, however, have a significant impact upon the managers' attitudes. When the "low religiousness" students and managers were compared, differences were found with (...) respect to the economic, ethical, and philanthropic components of corporate social responsibility. Similar results were obtained when the "high religiousness" students and managers were compared. The implications of these findings are discussed. (shrink)

The first set of case studies on animal use, this volume offers a thorough, up-to-date exploration of the moral issues related to animal welfare. Its main purpose is to examine how far it is ethically justifiable to harm animals in order to benefit mankind. An excellent introduction provides a framework for the cases and sets the background of philosophical and moral concepts underlying the subject. Sixteen original, previously unpublished essays cover controversies associated with the human use of animals in a (...) broad range of contexts, including biomedical, behavioral, and wildlife research, cosmetic safety testing, education, the food industry, commerce, and animal use as pets and in religious practices. Scientific research is accorded the closest scrutiny. The authors represent a wide range of expertise within their specialized areas of research--physiology, public policy, ethics, philosophy, law, veterinary science, and psychology. The careful analysis of each case makes it possible to elevate the discourse beyond over-simplified positions, and to demonstrate the complexity of the issues. The Human Use of Animals will be welcomed by students and faculty in law, philosophy, ethics, public policy, religion, medicine, and veterinary medicine. It will also interest activists in the animal protection movement, and members of animal protection organizations and Institutional Animal Care and Use Committees. (shrink)

Theories of cognitive development must address both the issue of how children bring their knowledge to bear on behavior in-the-moment, and how knowledge changes over time. We argue that seeking answers to these questions requires an appreciation of the dynamic nature of the developing system in its full, reciprocal complexity. We illustrate this dynamic complexity with results from two lines of research on early word learning. The first demonstrates how the child's active engagement with objects and people supports referent selection (...) via memories for what objects were previously seen in a cued location. The second set of results highlights changes in the role of novelty and attentional processes in referent selection and retention as children's knowledge of words and objects grows. Together this work suggests that understanding systems for perception, action, attention, and memory, and their complex interaction, is critical to understand word learning. We review recent literature that highlights the complex interactions between these processes in cognitive development and point to critical issues for future work. (shrink)

Replicating or exceeding human intelligence, not just in particular domains but in general, has always been a major goal of Artificial Intelligence (AI). We argue here that “human intelligence” is not only ill-defined, but often conflated with broader aspects of human psychology. Standard arguments for replicating it are morally unacceptable. We then suggest a reframing: that the proper goal of AI is not to replicate humans, but to complement them by creating diverse intelligences capable of collaborating with humans. This goal (...) renders issues of theory of mind, empathy, and caring, or community engagement, central to AI. It also challenges AI to better understand the circumstances in which human intelligence, including human moral intelligence, fails. (shrink)

A new axiomatization of set theory, to be called Bernays-Boolos set theory, is introduced. Its background logic is the plural logic of Boolos, and its only positive set-theoretic existence axiom is a reflection principle of Bernays. It is a very simple system of axioms sufficient to obtain the usual axioms of ZFC, plus some large cardinals, and to reduce every question of plural logic to a question of set theory.

Darwinism, Democracy, and Race examines the development and defence of an argument that arose at the boundary between anthropology and evolutionary biology in twentieth-century America. In its fully articulated form, this argument simultaneously discredited scientific racism and defended free human agency in Darwinian terms. The volume is timely because it gives readers a key to assessing contemporary debates about the biology of race. By working across disciplinary lines, the book's focal figures--the anthropologist Franz Boas, the cultural anthropologist Alfred Kroeber, the (...) geneticist Theodosius Dobzhansky, and the physical anthropologist Sherwood Washburn--found increasingly persuasive ways of cutting between genetic determinist and social constructionist views of race by grounding Boas's racially egalitarian, culturally relativistic, and democratically pluralistic ethic in a distinctive version of the genetic theory of natural selection. Collaborators in making and defending this argument included Ashley Montagu, Stephen Jay Gould, and Richard Lewontin. Darwinism, Democracy, and Race will appeal to advanced undergraduates, graduate students, and academics interested in subjects including Philosophy, Critical Race Theory, Sociology of Race, History of Biology and Anthropology, and Rhetoric of Science. (shrink)

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

This book will appeal to mathematicians and philosophers interested in the foundations of mathematics.

In lieu of an abstract, here is a brief excerpt of the content:John P. Anton C. P. CAVAFY'S ARS POETICA ' It is generally recognized that Constantine P. Cavafy (1863-1933) was not born a poet but became one only through persistence and labor, reaching his "first step" sometime after the midpoint of his life. In his effort to assess the quality of his earlier poetic production and sharpen his sensitivity in facing self-criticism, he decided to put in writing his (...) personal thoughts on his work sometime in 1903. The text was written in English in a personal shorthand Cavafy had devised for his own use. It was found among the papers he left to A. Sengopoulos and published for the first time in 1963 by M. Peridis, who also supplied the suitable title Ars Poetica. It falls outside the scope of this essay to discuss the antecedents of this document. Taken as a whole, the text has all the clarity and directness required of a testament designed to serve as a personal guide and handbook. The problems it discusses are limited to the needs of the poet. In this regard, the Ars Poetica has neither the range of topics nor the theoretical scope of, for instance, Aristotle's Poetics. It is quite certain that the ideas that preoccupy Cavafy in the Ars Poetica had been on his mind for a period of years. However, the Ars Poetica is his first prose piece where he gives a systematic treatment to technical and critical issues directly related to the assessment of his work and his role as a poet. In order to project here a clear image of Cavafy's struggle to reach his technical maturity which came after 1910, we need first to discuss the persistent problems he faced during this crucial decade, then to examine the attitudes and values he embodied in certain representative early poems, and finally to relate them to the guiding principles he formulated in his self-addressed poetics of 1903. A number of interrelated problems confronted Cavafy in his late twenties and throughout his thirties. They emerged one by one, to 85 86Philosophy and Literature make more pressing the demand for a consistent solution and a complete recasting of his outlook. Coming to terms with them was extremely difficult. Aside from the emotional and sexual pressures he had to face alone, there was the absence of suitable ideas and conceptual tools to provide him with even the rudiments of an intellectual framework. Whatever he borrowed from Europe and England, or resurrected from his own Hellenic heritage, proved either beyond assimilation or insufficiently digested. The lingering issues fell roughly into four areas. (i) Despite his determination to devote his life to the writing of poetry, the quality of his work was discouraging. He knew this and as a result he often expressed uncertainty about his ability to proceed. Time and again he appeared suffering from a feeling of inadequacy, but nevertheless he sought to engage a reflective mood from which to draw encouragement and hope. (ii) On the theoretical side, he identified with the long tradition which assigned a coveted cultural role to the savant-poet as discloser of truth and spokesman for humanity; this despite the prevailing climate of opinion in his immediate environment which recognized no such high position in his case. Cavafy knew that his standing with the Greek community of Alexandria had gradually dwindled with the loss of family wealth and his lowly employment, and also that his expectations to be respected in his role as a poet and leader in communal affairs were futile. This denial of personal recognition in a society dominated by commerce and finance contributed to his mood of depression. The feeling of being an outcast, despite his associations with the upper social circles of Alexandria, became a constant irritant to his sense of pride. (iii) The course of culture, the destiny of human institutions and the workings of history, became puzzles as he tried to view them through the opaque glass of disillusionment. These were the grand themes actively discussed in the writings of leading European intellectuals, but to the young poet they had a different personal urgency. His vital concern in this connection was not understanding science... (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The complexity of the set of truths of arithmetic is determined for various theories of truth deriving from Kripke and from Gupta and Herzberger.

The great logician Gottlob Frege attempted to provide a purely logical foundation for mathematics. His system collapsed when Bertrand Russell discovered a contradiction in it. Thereafter, mathematicians and logicians, beginning with Russell himself, turned in other directions to look for a framework for modern abstract mathematics. Over the past couple of decades, however, logicians and philosophers have discovered that much more is salvageable from the rubble of Frege's system than had previously been assumed. A variety of repaired systems have been (...) proposed, each a consistent theory permitting the development of a significant portion of mathematics. This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in each. John Burgess considers every proposed fix, each with its distinctive philosophical advantages and drawbacks. These systems range from those barely able to reconstruct the rudiments of arithmetic to those that go well beyond the generally accepted axioms of set theory into the speculative realm of large cardinals. For the most part, Burgess finds that attempts to fix Frege do less than advertised to revive his system. This book will be the benchmark against which future analyses of the revival of Frege will be measured. (shrink)

Numbers and other mathematical objects are exceptional in having no locations in space or time or relations of cause and effect. This makes it difficult to account for the possibility of the knowledge of such objects, leading many philosophers to embrace nominalism, the doctrine that there are no such objects, and to embark on ambitious projects for interpreting mathematics so as to preserve the subject while eliminating its objects. This book cuts through a host of technicalities that have obscured previous (...) discussions of these projects, and presents clear, concise accounts of a dozen strategies for nominalistic interpretation of mathematics, thus equipping the reader to evaluate each and to compare different ones. The authors also offer critical discussion, rare in the literature, of the aims and claims of nominalistic interpretation, suggesting that it is significant in a very different way from that usually assumed. (shrink)

Over the past several years, healthcare has been profoundly altered by the growth of managed care. Because managed care integrates the financing and delivery of healthcare services, it dramatically alters the roles and relationships among providers, payers, and patients. While analysis of this change has focused on whether and how managed care can control costs, an increasingly important concern among healthcare providers and recipients is the impact of managed care on the physicianpatient relationship, but little data have been collected and (...) analyzed. We designed a survey for distribution to Wisconsin physicians to analyze the prevalence and types of managed care arrangements in the state, and the impact of these arrangements on physicians and their relationships with patients. (shrink)

The source, status, and significance of the derivation of the necessity of identity at the beginning of Kripke’s lecture “Identity and Necessity” is discussed from a logical, philosophical, and historical point of view.

We have shown in a previous paper that the Dirac bispinor can vary like a four-vector and that Quantum Electrodynamics can be reproduced with this form of behaviour. In Part I of this paper, we show that QED with the same transformational behaviour also holds in an alternative space we call M-space. We use the four-vector behaviour to model the two-body interaction in M and show that this has similar physical properties to the usual model in L which it predicts. (...) In Part II of this paper we use M-space to show that QED can be reduced to two simple rules for a two-body interaction. (shrink)

: In this commentary we engage with Paul’s Transformative Experience as it relates to decision making. We consider why deciding whether to undergo a transformative experiences can feel so agonizing yet also be so fun, whether people have any preferences to decide over in the first place, and who people even think they are. Keywords: Transformative Experience; Big Decisions; Preference Construction; Theory of Self; Mental Effort Decisioni trasformative e relative insoddisfazioni Riassunto: In questo commento ci concentreremo su come il volume (...) di L.A. Paul Transformative Experience affronta i processi decisionali. Esamineremo perché la decisione se intraprendere un’esperienza trasformativa possa risultare così struggente ed essere altresì divertente; se le persone abbiano in assoluto qualche preferenza nel prendere decisioni definitive e chi le persone persone ritengono di essere. Parole chiave: Esperienza trasformativa; Grandi decisioni; Costruzione delle preferenze; Teoria del sé; Sforzo mentale. (shrink)

Critics of organ donation after circulatory death (DCD) argue that, even if donors are past the point of autoresuscitation, they have not satisfied the “irreversibility” requirement in the circulatory and respiratory criteria for determining death, since their circulation and respiration could be artificially restored. Thus, removing their vital organs violates the “dead-donor” rule. I defend DCD donation against this criticism. I argue that practical medical-ethical considerations, including respect for do-not-resuscitate orders, support interpreting “irreversibility” to mean permanent cessation of circulation and (...) respiration. Assuming a consciousness-related formulation of human death, I then argue that the loss of circulation and respiration is significant, because it leads to the permanent loss of consciousness and thus to the death of the human person. The DNR request by an organ donor should thus be interpreted to mean “do not restore to consciousness.” Finally, I respond to an objection that if “irreversibility” has a medical-ethical meaning, it would entail the absurd possibility that one of two individuals in the same physical state could be alive and the other dead—an implication that some think is inconsistent with understanding death as an objective biological state of the organism. I argue that advances in medical technology have created phenomena that challenge the assumption that human death can be understood in strictly biological terms. I argue that ethical and ontological considerations about our nature bear on the definition and determination of death and thus on the permissibility of DCD. (shrink)

Philosophical defenses of cognitive/evolutionary psychological accounts of racialism claim that classification based on phenotypical features of humans was common historically and is evidence for a species-typical, cognitive mechanism for essentializing. They conclude that social constructionist accounts of racialism must be supplemented by cognitive/evolutionary psychology. This article argues that phenotypical classifications were uncommon historically until such classifications were socially constructed. Moreover, some philosophers equivocate between two different meanings of “racial thinking.” The article concludes that social constructionist accounts are far more robust (...) than psychological accounts for the origins of racialism. (shrink)

Highlighting previously neglected democratic strains in Machiavelli's major writings, McCormick excavates institutions through which the common people of ancient, medieval, and Renaissance republics constrained the power of wealthy citizens and public magistrates, and he imagines how such institutions might be revived today.

This volume reprints a dozen of the author’s papers, most with substantial postscripts, and adds one new one. The bulk of the material is on topics in philosophy of language, but there are also two papers on philosophy of mathematics written after the appearance of the author’s collected papers on that subject, and one on epistemology. As to the substance of Field’s contributions, limitations of space preclude doing much more below than indicating the range of issues addressed, and the general (...) orientation taken towards them. As to the style of his writing, it well exhibits the first of the two virtues, clarity and conciseness, that one looks for in philosophical prose. (shrink)

Nominalism is the view that mathematical objects do not exist. This chapter delimits several types of nominalistic projects: revolutionary programs that attempt to change mathematics and hermeneutic programs that attempt to interpret mathematics. Some programs accord with naturalism, and some oppose naturalism. Steven Yablo’s fictionalism is brought into the fold and discussed at some length.

In this paper I show how what came to be known as “the double law of habit,” first formulated by Joseph Butler in a discussion of moral psychology in 1736, was taken up and developed by medical physiologists William Porterfield, Robert Whytt, and William Cullen as they disputed fundamental questions regarding the influence of the mind on the body, the possibility of unconscious mental processes, and the nature and extent of voluntary action. The paper shows, on a particular topic, the (...) overlap between eighteenth-century philosophical writings on the science of human nature on the one hand,and medical writings and lectures in physiology on the other. Other early modern writers discussed in the paper include René Descartes, Herman Boerhaave and David Hume. (shrink)

This is the first in-depth critical appraisal in English of the political, legal, and cultural writings of Carl Schmitt, perhaps this century's most brilliant critic of liberalism. It offers an assessment of this most sophisticated of fascist theorists without attempting either to apologise for or demonise him. Schmitt's Weimar writings confront the role of technology as it finds expression through the principles and practices of liberalism. Contemporary political conditions such as disaffection with liberalism and the rise of extremist political organizations (...) have rendered Schmitt's work both relevant and insightful. John McCormick examines why technology becomes a rallying cry for both right- and left-wing intellectuals at times when liberalism appears anachronistic, and shows the continuities between Weimar's ideological debates and those of our own age. (shrink)

Cognitive Science, Volume 46, Issue 5, May 2022.

In order to sketch an account of a moral commitment to persons as such, the essay examines empathy, sympathy, and benevolence as they arise first in special relations and then are reconstructed to include the stranger under the rubric of "extensive benevolence" or "universal love." The account, the author argues, must deal with conceptual empowerment and authorizing reasons, weakness and evil, normative conflict, and the relation of benevolence to justice.

This paper is the third of a multi-part examination of the Babylonian mathematical lunar theories known as Systems A and B. Part I (Britton, AHES 61:83–145, 2007) addressed the development of the empirical elements needed to separate the effects of lunar and solar anomaly on the intervals between syzygies, accomplished in the construction of the System A lunar theory early in the fourth century B.C. Part II (Britton, AHES 63:357–431, 2009) examines the accomplishment of this separation by the construction of (...) a successful theory depicting the variations due to lunar anomaly in System A and its subsequent adaptation in System B. The present paper examines the introduction of the uniform zodiac, necessary for any theory depicting variations depending on the position of syzygy. It addresses three questions: (1) In light of all available evidence, what is the magnitude of the constant term in the expression Δλ* = C − 1.3828°Y, describing the difference between the Babylonian sidereal longitudes and modern tropical longitudes? (2) What considerations governed the placement of the Babylonian sidereal zodiac relative to the fixed stars? (3) When was the uniform zodiac introduced? To the first question it finds C = 3.20° ± 0.1°, scarcely different from Huber’s (Centaurus 5:192–208, 1958) estimate of 3.08°, essentially confirming Huber’s result obtained from much less data. For the second it shows that accommodating the three asterisms comprising Taurus limited the placement of the zodiac to within 3°, while the prominence of half sign multiples among the measured intervals between prominent Normal Stars led irresistibly to the choice adopted. Finally, it finds that the zodiac was introduced between −408 and −397 and probably within a very few years of −400. (shrink)

In this paper I discuss whether Gödel's incompleteness theorems have any implications for studies in Artificial Life (AL). Since Gödel's incompleteness theorems have been used to argue against certain mechanistic theories of the mind, it seems natural to attempt to apply the theorems to certain strong mechanistic arguments postulated by some AL theorists. -/- We find that an argument using the incompleteness theorems can not be constructed that will block the hard AL claim, specifically in the field of robotics. However, (...) we will see that the beginnings of an argument casting doubt on our ability to create living systems entirely resident in a computer environment might be suggested by looking at the incompleteness theorems from the point of view of Gödel's belief in mathematical realism. (shrink)

There has been growing concern about whether individuals who satisfy neurological criteria for death or who become non-heart-beating organ donors are really dead. This concern has focused on the issue of the potential for recovery that these individuals may still have and whether their conditions are irreversible. In this article I examine the concepts of potentiality and irreversibility that have been invoked in the discussions of the definition of death and non-heart-beating organ donation. I initially focus on the recent challenge (...) by D. Alan Shewmon to accepting any neurological criterion of death. I argue that Shewmon relies on a problematic and unrealistic concept of potentiality, and that a better, more realistic concept of potentiality is consistent with accepting a neurological criterion for death. I then turn to an analysis of how the concept of irreversibility has been used in discussion of non-heart-beating organ donation. Similarly, I argue that some participants in this discussion have invoked a problematic and unrealistic concept of irreversibility. I then propose an alternative, more realistic account of irreversibility that explains how "irreversibility" should be understood in the definition and criteria of death. (shrink)

Scientific authorship has become a contested terrain in contemporary science. Based on a survey of authors across fields, we measure the likelihood of specialist authors : people who only made specialized contributions, such as data, materials, or funding; and “nonauthor collaborators” : those who did significant work on the project but do not appear as authors, across different research contexts, including field, size of the project team, commercial orientation, impact of publication, and organization of the collaboration. We find that guest (...) and ghost authors are common, with about one-third of publications having at least one specialist author and over half having at least one nonauthor collaborator. We see significant cross-field variations in both overall rates and types of specialist authors and nonauthor collaborators. We find there are generally fewer specialist authors among highly cited papers and more graduate student nonauthor collaborators in single location projects. The results suggest authorship practices vary across fields, and by project characteristics, complicating the use of authorship lists as a basis for evaluation. We discuss implications of these findings for interpreting author lists in the context of science policy. (shrink)

The species of indeterminist tense logic called Peircean by A. N. Prior is proved to be recursively decidable.

Earlier results on eliminating numerical objects from physical theories are extended to results on eliminating geometrical objects.